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Melatonin: Understanding Indications, Dosages and Timing

Melatonin: Understanding Indications, Dosages and Timing

Deepak-Shrivastava-photo

Deepak Shrivastava, MD

The demand for over the counter melatonin continues to increase while the scientific research findings and clinical evidence remains relatively less than optimal for most indications.  Little was known about the pineal gland in until 1958 where Lerner reported that it secreted melatonin. However, the Greeks described it as the Realm of Thought; Descartes called it the Seat of the Soul. In Eastern medicine it has long been associated with the ‘Third Eye’ and intuition, and it is linked to an important energy chakra. While on one hand there are claims associating melatonin with delayed ageing, cancer fighting properties, improved sexual vitality and cure for insomnia; on the other concerns regarding possible side effects like headache, depression, dizziness, daytime sleepiness, irritability and stomach cramps are well documented.1 Melatonin is considered possibly unsafe to use during pregnancy and breast-feeding. Since melatonin interacts with other hormones in the body and might be unsafe to use in people who have bleeding disorders, high blood pressure, diabetes, seizure disorder, depression and organ transplantation.

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Understanding the Report of a Sleep Study

Deepak-Shrivastava-photo

Deepak Shrivastava, MD, FAASM, RPSGT

(A Sleep Specialist)

A ‘Sleep Study’, also known as polysomnography or PSG, has been used for decades to diagnose and evaluate the severity of sleep apnea or reversible cessation of breathing during sleep.  Sleep apnea, sometimes called obstructive sleep apnea, is a common health problem that affects millions of men and women. It occurs in children as well. The potential life-threatening effects of sleep apnea include heart and blood pressure problems, anxiety, depression and other mental health problems and difficulty is controlling blood sugar and cholesterol levels.  An increasing number of sleep studies are being conducted as more people are becoming aware of the importance of good quality sleep and doctors are evaluating more people with sleep apnea symptoms. The presenting symptoms could be as subtle as daytime fatigue, tiredness, non-refreshing sleep or more intense like snoring, daytime sleepiness, and bed-partner noticing complete cessation of breathing until an awakening (can occur every few seconds to every couple of minutes).

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Why women sleep worse than men

Originally posted by SHELLEY WHITE, Special to The Globe and Mail

This is the third of a nine-part print and online series looking at the science of sleep and the vital role of sleep in maintaining overall health.

Like millions of Canadian mothers, Dawn Trudeau’s sleep troubles began when her daughter was born.

“You’re getting up at all hours for feedings and whatnot, and I had a hard time getting her to sleep through the night,” says the Ottawa-based, 46-year-old social media marketer and blogger at TheModernMomBlog.com. “My husband is great, and he would help in a minute but he just did not hear the baby crying,” she says.

Even after her daughter started sleeping through the night consistently at age 4, Ms. Trudeau says her sleeping problems persisted to the point of insomnia. “I kind of got used to it at that point.” And now that her daughter is 7, her sleep disturbances are also business-related.

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Fibromyalgia – Does Melatonin Help?

Originally posted in National Pain Report on August 24, 2015

Talk to a person who suffers from fibromyalgia and it doesn’t take long for the topic of sleep to come up.

“I’ve had major issues with sleeping,” said Jenny Schwarz who is from East Helena, Montana. “I have heard that a full night’s rest would greatly reduce my pain, but I don’t remember the last time I slept through the night.”

Is melatonin a possible answer?

Natural levels of melatonin in the blood are highest at night. According to the Mayo Clinic, Some research suggests that melatonin supplements taken at the right time might be helpful in treating jet lag or other sleep disorders that involve poor alignment of your natural biological clock with the night-day pattern around you. Melatonin might also reduce the time it takes to fall asleep — although this effect is typically mild

Now there’s world that several studies have shown that melatonin supplements can reduce pain in patients who have fibromyalgia.

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Sleep Apnea Linked To Migraine, Panic Disorder, Hearing And Other Things You Need To Know

Originally posted in Tech Times By Rina Marie Doctor, Tech Times | July 27, 9:54 AM

Sleep

Previous studies suggest that both depressive and anxiety disorders emerge after a diagnosis of sleep apnea had been made. However, the exact association between sleep apnea and panic disorder is not clearly established and so a group of researchers decided to investigate on their relationship. Migraines and hearing impairments are also being linked to sleep apnea in other literatures.

A group of researchers, who studied the association of panic disorder and sleep apnea obtained their data from patients diagnosed with sleep apnea from 2000-2010 through the Taiwan National Health Insurance Research Database. The researchers found that out of 43,496 participants, 263 were stricken by panic disorder after a mean follow-up period of 3.92 years. With this, the researchers acknowledge that sleep apnea may be a risk factor for panic disorder and recommend physicians to consider the comorbid factor of panic disorder in patients with sleep apnea.

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Oravan Sleep Apnea Device Gains Traction in Sleep Industry

Originally posted in PR Rocket on July 31, 2015

With the advancement of sleep apnea treatment technology, OravanOSA has introduced its FDA cleared Mandibular Advancement Device, aimed to move the jaw forward, further opening the upper airway for easy breathing.

West Orange, NJ (PRWEB) July 31, 2015

With the recent buzz surrounding the dangers of obstructive sleep apnea (OSA) and the growing number of individuals who remain undiagnosed, treatment options for patients are becoming more prevalent than ever before. As millions of Americans continue to shy away from traditional CPAP therapy due to its overall lack of comfort and highly invasive nature, oral appliances provided by dentists are gaining extreme popularity.

Mandibular Advancement Devices (MADs) move the lower jaw forward further opening the upper airway to allow for easy breathing. Of the many MADs on the market today, the Oravan device, manufactured by OravanOSA, has captured the attention of many in the sleep industry.

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The Curious Sleep Apnea and Heart Rhythm Connection

 

After surgery, a patient with sleep apnea discovered she also had atrial fibrillation, a serious irregular heart rhythm.

 

Up to half of people with atrial fibrillation may also have trouble breathing while they sleep.

Dealing with one chronic condition can be difficult; dealing with two or more amps up the challenge for your heart. That’s something all too familiar to Rhonda Marie Clare Harvey-Collens, 52, of Mount Pearl, Newfoundland and Labrador, Canada. She lives with rheumatoid arthritis, sleep apnea, and the abnormal heart rhythm known as atrial fibrillation.

Harvey-Collens was diagnosed with atrial fibrillation in 2007 while recovering from surgery for a life-threatening infection. The biologic drug she was taking for rheumatoid arthritis suppressed her immune system, and an infection took hold. This happened not once, but twice.

“When doing my vital signs, they realized something was not quite right with my pulse and discovered I had atrial fibrillation,” Harvey-Collens says.

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Better sleep may be important for Alzheimer’s risk – study

AP Saturday Jul 25, 2015

New research suggests poor sleep may increase people’s risk of Alzheimer’s disease, by spurring a brain-clogging gunk that in turn further interrupts shut-eye.

Disrupted sleep may be one of the missing pieces in explaining how a hallmark of Alzheimer’s, a sticky protein called beta-amyloid, starts its damage long before people have trouble with memory, researchers reported at the Alzheimer’s Association International Conference.

“It’s very clear that sleep disruption is an underappreciated factor,” said Dr. Matthew Walker of the University of California, Berkeley, who presented data linking amyloid levels with people’s sleep and memory performance. “It’s a new player on the scene that increases risk of Alzheimer’s disease.”

Sleep problems are treatable – and a key next question is whether improving sleep can make a difference in protecting seniors’ brains.

http://www.nzherald.co.nz/lifestyle/news/article.cfm?c_id=6&objectid=11484259

Enough sleep is important for good health generally ” seven to eight hours a night are recommended for adults.

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Sleep Apnea – Pipeline Review, H2 2014 – Radiant Insights, Inc J

Originally posted in Medgadget on JULY 24TH, 2015 RADIANT INSIGHTS, INC.

 

Global Markets Direct’s, ‘Sleep Apnea – Pipeline Review, H2 2014′, provides an overview of the Sleep Apnea’s therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Sleep Apnea, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.

It also reviews key players involved in the therapeutic development for Sleep Apnea and special features on late-stage and discontinued projects.

To Get More Details @http://www.radiantinsights.com/research/sleep-apnea-pipeline-review-h2-2014

Global Markets Direct’s report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct’s proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct’s team.

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