Study Finds Cognitive Behavior Therapy More Effective Than Sleeping Pills For Treating Insomnia

Benefits of Non-Drug Techniques Top Most Popular Sleeping Pill, Ambien

Boston, MA - September 27, 2004

A study by researchers at Beth Israel Deaconess Medical Center (BIDMC) has found that cognitive behavioral therapy (CBT) is more effective than sleeping pills in treating chronic sleep-onset insomnia.

The findings, which appear in the Sept. 27 issue of the Archives of Internal Medicine, show non-drug techniques yield better short and long-term results than the most widely prescribed sleeping pill, zolpidem, commonly known as Ambien. It is the first placebo-controlled trial to evaluate the separate and combined effects of CBT and pharmacological therapies in treating insomnia in young and middle-aged adults.

"Sleeping pills are the most frequent treatment for insomnia, yet CBT techniques clearly were more successful in helping the majority of study participants to become normal sleepers. Sleeping pills were only moderately effective compared to CBT and they lost their effectiveness as soon as they were discontinued, " said study leader Gregg Jacobs, Ph.D., insomnia specialist in the Sleep Disorders Center of BIDMC and an assistant professor of psychiatry at Harvard Medical School.

"Our results suggest that CBT should be considered the first line treatment for insomnia, which is experienced on a nightly basis by one-third of the nation’s adult population," added Jacobs.

Insomnia affects more than 70 million Americans and is one of the most common complaints brought to physician’s offices. Those with the condition experience difficulty initiating or maintaining sleep, often resulting in impaired daytime functioning. In the National Sleep Foundation’s 2002 Sleep in America poll, 35 percent of all adults experienced symptoms every night, with 58 percent reporting insomnia at least a few nights per week.

For the study, researchers conducted a randomized, placebo-controlled clinical trial involving 63 young and middle-aged adults with chronic sleep-onset insomnia. Interventions included behavioral and relaxation techniques, pharmacotherapy (using Ambien), or combined therapy compared with placebo. Researchers measured sleep at baseline and then twice during an eight week treatment period: at mid-treatment when pharmacotherapy subjects were still taking a nightly dose of Ambien, and at the end of the eight week treatment period when Ambien subjects gradually tapered their medication and then discontinued it entirely. The main outcome measure was sleep-onset latency as shown by patient sleep diaries. Secondary measures included sleep efficiency and total time as derived from the diaries, objective measures of variables using objective sleep recordings, and an assessment of daytime functioning.

Amongst the findings, the CBT and combination groups showed the greatest changes in sleep-onset latency at mid-treatment, both registering a 44 percent reduction. Pharmacotherapy subjects showed a modest 29 percent reduction in sleep-onset latency, followed by 10 percent for the placebo group. At the end of the eight week treatment period, CBT and combination treatment yielded a 52% reduction on sleep-onset latency, which was maintained at long-term follow-up. The moderate improvements observed in the Ambien group at mid-treatment were not maintained after the drug was gradually tapered and then discontinued. In fact, by the end of the eight week treatment phase, insomnia returned almost to pre-treatment levels after discontinuation of Ambien and did not differ from placebo. CBT and combined therapy also produced the greatest improvements in sleep efficiency and yielded the greatest number of normal sleepers by the end of treatment on measures of sleep onset latency and sleep efficiency. There was no advantage of combined therapy over CBT alone and no significant differences emerged amongst groups in total sleep time, though all exhibited increases. The results from the objective sleep recordings paralleled the sleep dairy results.

Despite the fact sleeping pills are the most frequently prescribed treatment for insomnia, and newer generation sleep medications are being introduced to the U.S. market, they are not recommended for long-term treatment of insomnia due to numerous and well-documented side effects such as dependency.

Prior studies also indicate that insomnia patients prefer non-drug approaches.

Study co-authors include Edward Franz Pace-Schott, MS, BIDMC psychiatry; Robert Stickgold, PhD, BIDMC psychiatry; Michael W. Otto, Ph.D.., Massachusetts General Hospital and Harvard Medical School.

This research was funded by a grants from the National Institutes of Health.

Beth Israel Deaconess Medical Center is a major patient care, teaching and research affiliate of Harvard Medical School, and ranks third in National Institutes of Health funding among independent hospitals nationwide. BIDMC is clinically affiliated with the Joslin Diabetes Center and is a research partner of Dana-Farber/Harvard Cancer Center. BIDMC is the official hospital of the Boston Red Sox. For more information, visit www.bidmc.harvard.edu.