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In 1995, the American Thoracic Society published a paper by Richards et al entitled Mouth Leak With Nasal Continuous Positive Airway Pressure Increases Nasal Airway Resistance (2). This paper revealed some significant facts:

Patients were using nasal CPAP at 12cm H 2 O with a calibrated mouth leak* of 50 L/min for 10 mins. This graph compares NAR after the mouth leak has taken place. Every subject included in the study exhibited an increase in NAR following mouth leak.

A mouth leak was simulated while the patient was on CPAP with room air, cold passover humidification and heated humidification. Cold passover humidification caused little change in the patients' response to the challenge, but the heated humidifier minimized the increase in NAR and reduced recovery time.
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