All articles tagged Biomarkers for sleep apnea

An ancient molecule underlies the mechanism for sleep apnea and vascular problems

by Helen Dodson

An ancient molecule underlies the mechanism for sleep apnea and vascular problems
Credit: Shutterstock
(Medical Xpress)—The underlying mechanism of obstructive sleep apnea that causes damage to blood vessels and contributes to hypertension, stroke, and atherosclerosis has been identified by researchers from Yale and elsewhere. The finding points to potential biomarkers for early diagnosis and treatment of these conditions. The study appears in PLOS ONE.Obstructive sleep apnea (OSA) is characterized by recurrent upper airway obstruction while sleeping. It affects up to a fourth of all adults and is associated with increased risk of hypertension, stroke, and cardiovascular disease. But until now, the underlying mechanisms were not fully established.Current evidence suggests, the authors write, that , oxidative stress, and dysfunction in the inner lining of —the endothelium—play roles in the vascular complications of OSA. In addition, endothelial dysfunction is the earliest event in atherosclerosis and plays a pivotal role in all phases of that condition, including plaque rupture.
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