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How to Use Melatonin Correctly

How to Use Melatonin Correctly

Using melatonin correctly can help sleep and mood problems, but melatonin can be tricky, and if misused can cause insomnia and even depression. Here are some of the common mistakes people make, and guidelines to use melatonin the right way.

Mistake #1: Melatonin is a sleep hormone

Most people think melatonin is a natural sleeping pill. This couldn’t be more wrong; melatonin on its own won’t induce sleep, and is usually only effective in short-term applications. It’s more correct to think of melatonin as a ‘darkness’ signaler, that is, it tells the brain that it needs to prepare for a night time or winter cycle. If taken in the evening or when it’s dark, melatonin can speed up sleep preparation, and it can tell the body clock to shift its sleep cycle to an earlier time.

Mistake #2: I can take melatonin at any time.

If melatonin is used during daytime brightness, it can cause adverse effects. If the body clock is receiving conflicting daytime light signals and dark signals from melatonin, it can malfunction and not work properly when it is time to go to sleep later.

Mistake #3: Melatonin is a natural supplement, so it can’t do any harm.

The wrong amounts of melatonin or melatonin at the wrong time of day can cause serious health risks. Daytime melatonin has been shown to cause depression. This makes sense, especially when you consider that melatonin causes us to pull back, withdraw, become disoriented and irritable – the classic hibernation response. It’s best to avoid using melatonin that could be in our system during the day.

Mistake #4: I need melatonin to help me sleep

In most cases, your sleep problem isn’t from a lack of melatonin, and increasing melatonin can mask underlying problems that are the real cause of insomnia. If you need melatonin to help you fall or stay asleep, you are more likely suffering from a circadian rhythm sleep disorder. Circadian rhythm sleep disorders mean that your body is producing melatonin and other sleep hormones at the wrong time of day, so when you need to sleep, you don’t have enough melatonin in your system. Simply adding melatonin doesn’t fix the sleep problem and can contribute to depressive mood disorders. The most effective treatment for circadian rhythm sleep disorders is light therapy, because bright light is the zeitgeber or signaler the body clock uses to reset itself each day.

Mistake #5: I need to keep taking melatonin.

Sleep experts don’t recommend taking melatonin for more than two weeks at a time. Melatonin is effective as a signal augmenter (reinforcing external cues), or as a tool to help shift sleep and circadian rhythms. Long term use of melatonin indicates a more serious underlying sleep disorder that should be investigated by a sleep professional.

Mistake #6: The dosage amount isn’t important.

The problem with melatonin is that it was discovered long before scientists really understood what it does and how much you need. For example, in the late 80’s and early 90’s, we thought melatonin was a sleep hormone. Now we know it is much more complicated. In addition, tablet sizes average 3-5 mg. New evidence shows that adult males only need 150 micrograms, and the average female needs only 100 micrograms (a microgram is 1/100 th of a milligram). So the average melatonin supplement is 20 – 50 times more than we need! If you are using regular melatonin tablets, you can cut the pill into fourths, otherwise, try to find the smallest pill size available. If you are taking time-released melatonin, do not break the pill, as this will ruin the time-release.

Mistake #7: I don’t take melatonin, so I don’t have to worry.

Actually, this could be one of the costliest mistakes people make. Melatonin is an essential nighttime hormone. When in the body at the right time, it does wonderful things, such as help the heart and vital organs rest at night. Melatonin also acts as a powerful antioxidant; while it shuts the body down, it cleans the toxins and free radicals from cells.

But we often do things that keep melatonin from being produced, and that can be deadly. When we stay up late at night or work night shifts, we keep our body from producing melatonin. This increases the risk of hypertension, heart disease, diabetes and cancer. Studies show women night-shift workers have a 500% higher risk of breast cancer and male night shift workers have a 50% increased risk of colo-rectal and bone cancer. While not realizing it, many people increase this risk with inconsistent sleep/wake schedules – late night studying or partying or shift work schedules.

How should I take melatonin?

The first thing to know about melatonin is that its half life is very short, and is only active in your system for about 20 minutes. This is why it is important to use different types of melatonin for different reasons:

Induce sleep or shift sleep to an earlier schedule (1hr+)

  • If you take more than an hour to fall asleep, or you need to shift your sleep more than an hour, consider taking time-released melatonin. It is also important to use a high-quality, standardized melatonin supplement. Try to find the lowest dose available and do not cut the pill . Since melatonin tablets are coated to provide slow release, cutting them will ruin their long-term potency.
  • When to take: Depending on the severity of the sleep problem, take time-released melatonin 1 to 3 hours prior to the time you usually fall asleep. Since time release melatonin only lasts for 3 – 4 hours, any need to shift sleep schedules more than 3 hours may require taking another pill in 3 or 4 hours.
  • Cautions: Melatonin should not be taken if eyes are exposed to bright sunlight, and melatonin should be avoided if operating any vehicle. If attempting sleep shifts of more than 1 hour, light therapy should also be used. Do not use melatonin for more than two weeks at a time.

Induce sleep (less than 1hr)

  • If it takes an hour or less to fall asleep, then standard melatonin in the lowest mg size is a good option.
  • When to take: One to two hours before desired sleep time.
  • Cautions: See above

Nighttime awakenings and early morning insomnia

For nighttime awakenings that last less than one hour, consider taking sublingual melatonin (a pill that dissolves under the tongue). Sublingual melatonin is released immediately into the blood stream, and isn’t metabolized through the digestive system.

  • For frequent or awakenings that last more than one hour, consider taking 1 sublingual and a time-released melatonin tablet. Take the time release tablet first and then place the sublingual tablet under your tongue.
  • Cautions: If you need to get up in the morning within 2-3 hours, Take regular instead of time release melatonin. Time release melatonin may last into the waking hours, causing confusion and mood problems. Do not take melatonin if you awaken less than one hour before you need to get up.

Considering Light Therapy

As mentioned above, the need to use melatonin indicates a circadian rhythm disorder because sufficient melatonin is not in your system when you need to sleep. Melatonin on its own doesn’t regulate circadian rhythms, because your body’s control center relies on bright light to reset its daily sleep/wake rhythms. Melatonin can aid in shifting rhythms, but most of the effort in regulating circadian rhythms involves suppressing daytime melatonin. The problem isn’t that your body needs more melatonin – it produces enough, but when your body clock malfunctions, it produces melatonin at the wrong time of day, and specialized light keeps melatonin out of your system at the wrong time of day, so your body will produce it at the right time.


  • G W Lambert, et al. Effect of sunlight and season on serotonin turnover in the brain. The Lancet. Vol 360. December 7, 2002
  • Carskadon MA, Association between puberty and delayed phase preference. Sleep. 1993 Apr;16(3):258-62.
  • J Rabe-Jablonska et al., Diurnal profile of melatonin secretion in the acute phase of major depression and in remission. Med Sci Monit. 2001 Sep-Oct;7(5):946-52.

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Comments (36)

    • For anyone reading this with Bipolar: The answer is Circadin is probably not safe. Bipolar disorder is believed to be linked to the circadian rhythm and messing with that will likely aggravate the disorder. Avoid light therapy and melatonin as well.

  1. I have sleep problems due to my body not shutting down my legs are the worst I constantly have to keep them moving better know as RLS I have not been diagnosed with it but they won’t relax so I’ll take 5 pills of 3 mg melatonin by Natrol it shuts everything but my legs until it takes effect but if I wake up during the night my legs are too what is safe and effective for this problem ?

    • Welcome to my world. I’m a 51 year old wife and mother of 2. I inherited Restless Leg Syndrom from my father who suffered with it for many years. I have had it for about 15 years. But even worse is the fact that sometimes it is restless legs AND ARMS! Yup, you read that right. That is insane isn’t it? Along with that I have delicate (so I was told by my Dr.) vein walls. If I am on my feet for too long on the cement floors at my work my blood pools in the bottom of my legs and my feet and the veins swell, burn and throb and sometimes shows an indication of vericose veins.

      For Restless legs/arms I have had good results with a couple of recommendations online that I have found. Magnesium. I take it along with my calcium ( in the same pill) just before bed and it does an excellent job of preventing it. I take vitamins and suppliments anyways, so I just leave the calcium and magnesium for bedtime and the rest in the morning. Another, if that fails ( which it rarely does) is Ibuprofen. It also does an excellent job. There are prescription drugs for the condition but I probably will never resort to that. Too expensive with too many side affects. Hope this helps you. Brenda

    • Hi Replying to your emquiry about RESTLESS LEG SYNDROME ( RLS).

      I too suffered for years. USUALLY associated with iron and magnesium deficiency and Also put tissue salt mag phos under tongue. Use natural progesterone cream on area that is pulling.This cured my problem.

    • you are taking waaaay too much melatonin. did you even bother reading the article before jumping down here to the comments? maybe, instead of acting like an attention whore and wasting everybody’s time, you should GOOGLE RLS YOURSELF and come back and let us know what you found. you are selfish and vapid, and you’re making me sad.

  2. Why not try some natural remedies at first? There are a lot of things that could help you sleep and not result to taking up any drugs. A good one is lavender oil and camomile tea. Some breathing exercise in the morning and yoga is also a big factor that can help aid in sleeping disorder.

  3. Hi There,

    Regarding the point you made about ‘most’ people not needing Melatonin to sleep… I’m sure you are right but could I point out that it’s been shown (peer-reviewed studies) that some autistic people DO NEED it to sleep! This is because, and this may sound odd but it’s true, people up to 80% of people on the spectrum produce WAY too much Melatonin naturally. No one is entirely sure WHY this is the case but it certainly appears to be the case. Now, one might ask, why on earth would you give extra Melatnonin to someone who is already producing WAY too much… well, again, there are many theories but one of the commonest is that since so many of those who are diagnosed as being on the spectrum produce SO much more Melatonin than they need (the amount varies but it is considerably more than ‘normal’ or neuro-typical people produce) then perhaps the body becomes so overloaded with Melatonin that it simply has no idea how to use ANY of it and so kind of ‘gives it a miss’ (not very scientific but I can’t think of another, simple way to put it) and therefore taking Melatonin (varying amounts but often up to 6 mg is needed) at night (in particular in children on the spectrum who have the most pronounced and researched sleep problems) will very often improve the chances of going to sleep.

    Normally, for those on the spectrum (I am one!), the doctor will prescribe a multi-format Melatonin which is half immediate-release (mine for example has 2.5 mg immediate release) and half slow-release (mine has 2.5 mg which is slow release also, making a total of 5 mg) and this is because it doesn’t last efficaciously in the system for too long and so, commonly, a few hours after going to sleep (anything between 2 hours – 4 hours after falling asleep) the person will wake up again. Therefore, at that point, the slow-release kicks in and one can drop back to sleep again.

    Quite hard to explain it all in one post without droning on but it is important to note that those on the spectrum may well NEED Melatonin prescribed in order to sleep both effectively and functionally.

    Hope that’s informational and not preaching! 🙂

    • You’ve made a very good point here about melatonin with ASD. I’d especially like to note that you mentioned that “some” people with ASD need it. ASD is often very expressed very differently neurologically in different people so some people with ASD might not need it.

      I would like to add that their are two processes that control sleep and only one is influenced by melatonin (the C process). The other, the S process is influenced by sleep pressure. I’m very curious about if increasing the S process would compensate for the uncooperative C process. In other words, going longer without sleep or shorter sleep periods.

  4. Just to add that the synthetic form of Melatonin, as given in prescriptions, is ‘seen’ by the body in a very slightly different way and that is why, we think, that people on the autism spectrum who produce too much natural Melatonin, often find the synthetic Melatonin is ‘recognized’ and ‘utilized’ OK, while their own, naturally-produced Melatonin, is not. If that makes sense!

    • Thank you for the information, Elena! I have ASD and *severe* sleep issues, and was concerned when I read that I shouldn’t be taking it for more than a couple weeks, as I’ve been taking it nightly for like 6 months! Your response makes a lot of sense (and wasn’t preachy at all!) and I appreciate the info. I had never heard about this, and it is very interesting. 🙂

    • How much and what kind do you take? And how old are you? I am 53 and looking for something to help with bouts of insomnia. My husband said it makes him have strange dreams…Thank you kindly, Gail

    • Agreed. I take 10mg each night and have done so for years with no ill effects. I get a good night’s sleep. It’s a God send. For those of us with chemical imbalances and our bodies don’t produce enough, sometimes you have to supplement. If you are over 40 like me, or have fibromyalgia like me, you just need more.

  5. Rob,

    Specifically, how much melatonin do you and your wife take and how long befor speel? Do you take any break from it or take it constantly over many weks?


  6. I buy bottles of 3 mg melatonin and I can clearly tell the difference between taking one, two, three or six for that matter. My rhythm is probably off, buy there isn’t much I can do about it because of work schedules.

    l will take 2 or 3 five mg melatonin’s about an hour before o get off work. Them take a couple more when I get home. Sometimes I will wake up 3 or 4 hours latter and take 2 or 3 more so I can get seven or eight hours of sleep. So far so good, no adverse effects as far as I can tell.

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  9. I disagree with the comments about treating it like a sleeping pill. I suffered insomnia for over a year and tried everything. Nothing worked – including light therapy. Then I saw a Naturopath who recommended 5mg of Melatonin daily. She also suggested I get the “Now” brand of Melatonin because many other brands don’t seem to work and to get the vegetable gelatine capsules not tablets. From the first night I took it I have slept like a baby. I used to fall asleep at 4am. Now I can fall asleep at 10pm. I feel drowsy within 30 minutes of taking it and when I wake up I feel relaxed and I now always sleep deeply. My naturopath (like one of the posters here) has been taking one capsule every night for years with no side effects either. I think it’s remarkable. Also now when I don’t take melatonin I can still fall asleep easily. So something in my body seems to have realigned itself. And what’s more, it only costs $12 for a 12 month supply.

  10. As we age, our body’s ability to produce melatonin is reduced. This may contribute to the change in sleep patterns as we age. Melatonin has also be shown to improve recovery from stroke and has been used in very large doses with septic premature babies. My husband and I take 40 mg nightly along with magnesium (which also aids in preparing the body for sleep) and have no side effects.

  11. I have no problem going to sleep, but I wake up about three hours later and that is it. I can’t go back to sleep. This is every other day. On the other days, I sleep and am tired all day. If I take melatonin before a ‘sleepy’ day, I sleep heavily and have a hard time getting out of bed. What dosage should I take? When should I take it? Thank you Layna

  12. I think melatonin dosage is a very individual response. For some reason, the time-release melatonin makes me sick. The regular melatonin is great (I use a brand with stomach enzymes added). I have been reading the info about taking a lower dose, but I am elderly and ill; for me, nothing lower than 3 mg. or so seems to work– 3 mg. taken at various intervals throughout the night, that is. Since it only lasts for 20 min, and it takes me awhile to get things done before bed, I usually have to take it more than once. That is, if I take it too soon before bed, I am too zonked; but if I take it and then remember something I forgot to do, then I am awake and can’t get back to sleep. Also, it doesn’t last for me more than 4. 50 hrs., which is why I have to keep taking it. I am very light sleeper. I don’t know if this is “healthy” or not, but my doctor doesn’t seem to have a problem with it. Again, the time-release stuff made me sick.

    I also have DPSD (delayed phase sleep disorder), but haven’t been able to find a doctor who can treat me. If I do light therapy, it makes my migraines much, much worse. I’m sure all these things have a connection, but I don’t think that the experts have it quite figured it out, yet, for everyone.

    On the other hand, I try to turn my lights out at a decent hour. I suspect that late night brightness messes up my cycle. But if I turn them out too early, it doesn’t really work, either. It’s a perpetual guessing game. 🙁

    I am 65, btw. I suspect that some older people may require more– not less– of this drug.

    • I forgot to specify that I take 3 mg. TOTAL during the night, not 3mg. each time I wake up. I break one 1 mg. tab sub-lingual in half, each time. You may add this to my original post, if you like. Thanks.

  13. To gail – My husband and I use 1 mg two-part release melatonin from NOW company. I got it on Amazon. It has helped us both with deep sleep. I do get some balance problems from it when awaking in the middle of the night and getting up to use the bathroom. This is gone in the morning. I am researching finding a much smaller dose that is two part release. This type has a burst of melatonin at the beginning and then some later for those who wake up in the middle of the night and cannot sleep.

  14. hi all, i live in the uk and have not slept properly for years and it seems to be getting worse, there is no waking at 4am and trying to get back off to sleep as im awake at 2-3-4-usually. i work in the afternoons, exercise, inc taking the dog walks. its driving me mad.

  15. I disagree with your dosage evaluation. In my laboratory we measure 1000 micro-grams/milligram which means in line 5 of mistake #6 where you say “(a microgram is 1/100 th of a milligram)” it might be more accurate to say 10 micrograms are 1/100 if a milligram. I’m not sure how to check your credentials and your credibility since you hide your real identity behind a pen name, but I would assume that you are a doctor, or some kind of health professional, and not a journalist who reads research with no knowledge of the underlying science, but this this type of order of magnitude error, can cost professionals dearly. I have checked your references (as I always do when reading supposed “facts” on the internet, or articles written by journalists to try to gain some notoriety) and I saw no references to melatonin dosage, as a matter of fact the study cited in “Effect of sunlight and season on serotonin turnover in the brain” used subjects who were not taking any medication. I also saw no mention of melatonin use in the Carskadon article “Association between puberty and delayed phase preference”, so I’m wondering about your source material for the mcg dosages you suggest.
    Somewhat disappointing when I was expecting to be reading something from the “world leader in the sleep field by providing quality information, support and resources to sleep disorder patients, their family, friends and healthcare professionals”.

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  17. I´ve been taken melatonin daily for the last 6 years. I´been a nightworker since 1999. I am rarely sick. Maybe every 3-4 years.
    I take the melatonin 1 hour before sleep.
    On my working days i sleep from 14:00 to 20:30. On my free days I sleep from 0:00-6:30.

    I leave in Denmark Europe. And in the winter the sets at 15:30 o´clock

    Do I have a wrong cycle? Hope for some advices



  18. I used to take 30mg of Melatonin every night to be able to sleep. I’ve been through all kinds of meds to try to fix my insomnia problems, prescription, non prescription drugs like melatonin and tylenol PM (both of which I need high doses) and natural, most of which don’t work at all. I can’t sleep at all (not even for 1 minute) if I don’t take something…. Right now, I’m able to sleep with about 15 to 20mg of melatonin most nights, but the lower dosages suggested in the article has never worked for me.

  19. Hi, im a 15 year old female. I recently had a severe concussion and my doctor recommended melatonin to help me sleep. I used it for a while and my doctor told me I don’t need to use it anymore, but now I can’t fall asleep without it. Are there any suggestions on how to… Well get it “fixed”

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