All articles in Melatonin

Melatonin: Understanding Indications, Dosages and Timing

Melatonin: Understanding Indications, Dosages and Timing


Deepak Shrivastava, MD

The demand for over the counter melatonin continues to increase while the scientific research findings and clinical evidence remains relatively less than optimal for most indications.  Little was known about the pineal gland in until 1958 where Lerner reported that it secreted melatonin. However, the Greeks described it as the Realm of Thought; Descartes called it the Seat of the Soul. In Eastern medicine it has long been associated with the ‘Third Eye’ and intuition, and it is linked to an important energy chakra. While on one hand there are claims associating melatonin with delayed ageing, cancer fighting properties, improved sexual vitality and cure for insomnia; on the other concerns regarding possible side effects like headache, depression, dizziness, daytime sleepiness, irritability and stomach cramps are well documented.1 Melatonin is considered possibly unsafe to use during pregnancy and breast-feeding. Since melatonin interacts with other hormones in the body and might be unsafe to use in people who have bleeding disorders, high blood pressure, diabetes, seizure disorder, depression and organ transplantation.

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