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Study proposes novel treatment for narcolepsy

Published In Medical News

October 10, 2013

Lancet Neurology, a prestigious journal in its domain, publishes in its last issue, an article entitled “Pitolisant versus placebo and modafinil in patients with narcolepsy: a double-blind randomised trial” authored by Y. Dauvilliers and others from the HARMONY I study group which proposes a novel treatment for this orphan disease. It is accompanied by a Commentary entitled “A need for new treatments in narcolepsy”.

Narcolepsy is a rare disabling disorder mainly characterised by Excessive Daytime Sleepiness (EDS) and cataplexy, a sudden loss of muscular tone following various emotions. Present treatments comprise psychostimulants, like modafinil or amphetamine-like compounds, to fight EDS and sodium oxybate or antidepressants against cataplexy attacks. However these treatments are not fully satisfactory in terms of efficacy, tolerance or administration.

Pitolisant is the first representant of a new class of drugs to be introduced in the clinics, the histamine H3-receptor antagonists; it was designed in 3 European academic laboratories and developed by Bioprojet, a small independent French pharmaceutical company.

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Abstract: Effects of a Heated Tube on Sleep Quality, With Active Heated Humidification During CPAP Therapy In a Cool Sleeping Environment

Printed with permission from Fisher&Paykel Healthcare

Poster Session: Advances in Obstructive Sleep Apnea
Nilius, Georg, Domanski, Ulrike, Franke, Karl-Josef, Ruhle, Kral-Heinz
Chest 2005 128: 232S-a


To compare the effect of conventional humidification with ThermoSmart™ heated breathing tube humidification on sleep quality and patient symptoms.


  • 19 OSA patients, prospectively recruited.
  • Patients underwent two full nights of polysomnography (PSG), in a cool room, whilst on CPAP at their pre-determined therapeutic pressure. Their first night was randomized to either conventional heated humidification or ThermoSmart™ heated breathing tube humidification. Patients crossed over to the alternative treatment arm on their second night.
  • PSG parameters were analyzed to determine objective quality of sleep and subjective questionnaires were administered to determine patient symptoms/side effects of therapy.


results graph

results graph


If condensation forms in the CPAP tubing system sleep quality is considerably reduced. When using CPAP therapy in a cool room, the use of a heated humidifier with a heated breathing tube improves sleep quality and subjective symptom scores.

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